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The Hepatic Zonation Paradox Why Zone 3 Cells Are Both Most Vulnerable and Most Regenerative

Year: 2026

Type: article

Abstract: Liver injury preferentially affects Zone 3 (pericentral) hepatocytes due tochronic hypoxia pO = 30-35 mmHg, yet these same cells exhibit the fastest regenerativeresponse post-injury. This paradox has remained mechanistically unexplained.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18154556

Author: Stefan, Ionut Alexandru

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7119531653

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