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Visceral Adiposity Threshold for Irreversible Hypothalamic-Pituitary-Gonadal Axis Suppression: The Aromatase-SHBG Saturation Hypothesis

Year: 2026

Type: article

Abstract: Obesity is strongly associated with male hypogonadism, yet weightloss yields inconsistent improvements in testosterone levels across individuals. Themechanisms underlying this heterogeneity remain poorly understood.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18150261

Author: Stefan, Ionut Alexandru

Language: English

Topic: Hormonal and reproductive studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7119535105

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