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15 01 Base Architecture HG Prostatic Adenocarcinoma

Year: 2026
Type: article
Abstract: Prostatic adenocarcinoma exhibits remarkable heterogeneity and therapeutic resistance, particularly in high-grade (Gleason ≥ 8) cases. Traditional approaches treat this disease as a monolithicentity characterized by androgen dependency and uncontrolled proliferation. However, emerging evidence suggests that high-grade prostatic tumors represent complex ecosystems comprisingmultiple cellular archetypes occupying distinct spatial niches, each governed by specific ecosistem equilibria.
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W7119536167
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