Work

Biological Activities, Health Benefits and Synthesis of Equol and Its Derivatives: A Comprehensive Review

Year: 2026

Type: article

Abstract: Equol is a metabolite transformed from daidzein by intestinal microorganisms and has received extensive attention due to its various pharmacological activities and therapeutic potential. In recent years, with the in-depth study of the biological activity of equol, the development of its derivatives has gradually become a research hotspot. These derivatives may exhibit stronger biological activities or more extensive pharmacological effects through structural modification or functional optimization. This review describes the research progress of equol and its derivatives in recent years, with a focus on the expansion of the synthetic mechanism and pathway of equol and its derivatives, and the exploration of the biological activities and functional development of equol and its derivatives. These advances will lay the foundation for the development of equol based nutrition and targeted therapy, thus providing new ideas and methods for the treatment of related diseases.

Source: Food Science & Nutrition

DOI: 10.1002/fsn3.71443

Authors: Jiao‐Jiao Zhuo, Bing‐Juan Li, Meng‐Ran Tian

Institution: Tianjin University of Commerce

Language: English

Topic: Phytoestrogen effects and research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: hybrid

Estimated APC paid: $3,630