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08 01 Base Architecture Esophageal Squamous Cell Carcinoma ESCC

Year: 2026

Type: article

Abstract: Esophageal squamous cell carcinoma (ESCC) arises from chronic insults—gastroesophageal reflux, alcohol, tobacco—creating a biochemically hostile microenvironment characterized by lowpH (3.5-5.0), elevated reactive oxygen species (ROS), and continuous epithelial stress[1, 2].Unlike adenocarcinomas or hepatocellular carcinomas, ESCC exhibits compensatory hyperkeratinization (Kρ = 0.7) and moderate metabolic plasticity (Metabolic Survival Index MSSI =0.58), positioning it as an ”intermediate-aggressive” malignancy with high clonal resilience (CR= 0.75) driven by stromal protection rather than maximal proliferative capacity[3].

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18164227

Author: Stefan, Ionut Alexandru

Language: English

Topic: Esophageal Cancer Research and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7119538622

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