dGAMLSS: an exact, distributed algorithm to fit Generalized Additive Models for Location, Scale, and Shape for privacy-preserving population reference charts
Year: 2025
Type: article
Abstract: MOTIVATION: There is growing interest in estimating population reference ranges across age and sex to better identify atypical clinically-relevant measurements throughout the lifespan. For this task, the World Health Organization recommends using Generalized Additive Models for Location, Scale, and Shape (GAMLSS), which can model non-linear growth trajectories under complex distributions that address the heterogeneity in human populations.Fitting GAMLSS models requires large, generalizable sample sizes, especially for accurate estimation of extreme quantiles, but obtaining such multi-site data can be challenging due to privacy concerns and practical considerations. In settings where patient data cannot be shared, privacy-preserving distributed algorithms for federated learning can be used, but no such algorithm exists for GAMLSS. RESULTS: We propose distributed GAMLSS (dGAMLSS), a distributed algorithm that can fit GAMLSS models across multiple sites without sharing patient-level data. This includes specific considerations for the fitting of smooth functions at varying levels of communication efficiency. We demonstrate the effectiveness of dGAMLSS in constructing population reference charts across clinical, genomics, and neuroimaging settings and show that dGAMLSS is able to reproduce pooled reference charts and inference down to numerical differences. AVAILABILITY AND IMPLEMENTATION: An R package providing examples of the dGAMLSS algorithm, as well as functions for sharing and aggregating site-specific parameters, is available at https://github.com/hufengling/dGAMLSS.
Source: Bioinformatics
Authors: Fengling Hu, Jiayi Tong, Margaret Gardner, Chris Adamson, Sophie Adler, Aaron F Alexander-Bloch, Evdokia Anagnostou, Kevin M Anderson, Ariosky Areces-Gonzalez, Duncan E Astle, Bonnie Auyeung, Muhammad Ayub, Jong Bin Bae, Gareth Ball, Simon Baron-Cohen, Richard Beare, Saashi A Bedford, Vivek Benegal, Richard A I Bethlehem, Frauke Beyer, John Blangero, Manuel Blesa Cábez, James P Boardman, Matthew Borzage, Jorge F Bosch-Bayard, Niall Bourke, Edward T Bullmore, Vince D Calhoun, Mallar M Chakravarty, Christina Chen, Casey Chertavian, Gaël Chetelat, Yap S Chong, Aiden Corvin, Manuela Costantino, Eric Courchesne, Fabrice Crivello, Vanessa L Cropley, Jennifer Crosbie, Nicolas Crossley, Marion Delarue, Richard Delorme, Sylvane Desrivieres, Gabriel A Devenyi, Maria A Di Biase, Ray Dolan, Kirsten A Donald, Gary Donohoe, Lena Dorfschmidt, Katharine Dunlop, Anthony D Edwards, Jed T Elison, Cameron T Ellis, Jeremy A Elman, Lisa Eyler, Damien A Fair, Paul C Fletcher, Peter Fonagy, Carol E Franz, Lidice Galan-Garcia, Ali Gholipour, Jay Giedd, John H Gilmore, David C Glahn, Ian M Goodyer, P E Grant, Nynke A Groenewold, Faith M Gunning, Raquel E Gur, Ruben C Gur, Christopher F Hammill, Oskar Hansson, Trey Hedden, Andreas Heinz, Richard N Henson, Katja Heuer, Jacqueline Hoare, Bharath Holla, Avram J Holmes, Hao Huang, Jonathan Ipser, Clifford R Jack, Andrea P Jackowski, Tianye Jia, David T Jones, Peter B Jones, Rene S Kahn, Hasse Karlsson, Linnea Karlsson, Ryuta Kawashima, Elizabeth A Kelley, Silke Kern, Ki-Woong Kim, Manfred G Kitzbichler, William S Kremen, François Lalonde, Brigitte Landeau, Jason Lerch, John D Lewis, Jiao Li, Wei Liao, Conor Liston, Michael V Lombardo, Jinglei Lv, Travis T Mallard, Machteld Marcelis, Samuel R Mathias, Bernard Mazoyer, Philip McGuire, Michael J Meaney, Andrea Mechelli, Bratislav Misic, Sarah E Morgan, David Mothersill, Cynthia Ortinau, Rik Ossenkoppele, Minhui Ouyang, Lena Palaniyappan, Leo Paly, Pedro M Pan, Christos Pantelis, Min Tae M Park, Tomas Paus, Zdenka Pausova, Deirel Paz-Linares, Alexa Pichet Binette, Karen Pierce, Xing Qian, Anqi Qiu, Armin Raznahan, Timothy Rittman, Amanda Rodrigue, Caitlin K Rollins, Rafael Romero-Garcia, Lisa Ronan, Monica D Rosenberg, David H Rowitch, Giovanni A Salum, Theodore D Satterthwaite, H Lina Schaare, Russell J Schachar, Michael Schöll, Aaron P Schultz, Jakob Seidlitz, David Sharp, Russell T Shinohara, Ingmar Skoog, Christopher D Smyser, Reisa A Sperling, Dan J Stein, Aleks Stolicyn, John Suckling, Gemma Sullivan, Kevin Sun, Benjamin Thyreau, Roberto Toro, Nicolas Traut, Kamen A Tsvetanov, Nicholas B Turk-Browne, Jetro J Tuulari, Christophe Tzourio, Étienne Vachon-Presseau, Mitchell J Valdes-Sosa, Pedro A Valdes-Sosa, Sofie L Valk, Therese van Amelsvoort, Simon N Vandekar, Lana Vasung, Petra E Vértes, Lindsay W Victoria, Sylvia Villeneuve, Arno Villringer, Jacob W Vogel, Konrad Wagstyl, Yin-Shan S Wang, Simon K Warfield, Varun Warrier, Eric Westman, Margaret L Westwater, Heather C Whalley, Simon R White, A Veronica Witte, Ning Yang, B T Thomas Yeo, Hyuk Jin Yun, Andrew Zalesky, Heather J Zar, Anna Zettergren, Juan H Zhou, Hisham Ziauddeen, Dabriel Zimmerman, Andre Zugman, Xi-Nian N Zuo, Andrew A. Chen, Richard A.I. Bethlehem, Jakob Seidlitz, Hongzhe Li, Aaron Alexander-Bloch, Yong Chen, Russell T. Shinohara
Language: English
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,989
Awards: Medical Scientist Training Program, G9000011622, G9000084299, G9000130585, G9000170920, G9000249023, Radiomics for Clinically-Acquired Brain MRIs of Youth with Neurodevelopmental Disorders, Precision brain charts for imaging-genomics of schizophrenia and the psychosis spectrum, The Genetics of Personalized Functional MRI Networks
OpenAlex ID: W7119709793