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Evaluation of Different Doses of Tanacetum parthenium Extract (TPE) on Blood Biochemical Parameters and Oxidative Stress Liver Biomarkers of Fish

Year: 2026

Type: article

Abstract: Although medicinal plants can be used to reduce stress caused by transportation and handling and to prevent and treat certain diseases in fish, evaluating their safety for fish is essential before their use. This study aimed to evaluate the pharmacological effects and determine the safe dose of the Tanacetum parthenium (known as feverfew) extract (TPE) on blood biochemical parameters and the oxidative stress liver biomarker of common carp ( Cyprinus carpio ). In this study, fish were fed with doses of 0.0%, 0.5%, 1%, 2%, 5%, and 10% TPE per kg feed for 28 days. Next, blood biochemical parameters and hepatic oxidative biomarkers were measured to determine safe doses of the extract. The activities of aspartate aminotransferase (AST) and gamma‐glutamyl transpeptidase significantly increased ( p < 0.05) after feeding fish with 10% TPE. Conversely, there was a notable decrease ( p < 0.05) in alanine aminotransferase activity in the plasma of fish given 10% TPE. Furthermore, lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) activities in the plasma were significantly higher ( p < 0.05) in fish fed with either 5% or 10% TPE compared to the control group. Increasing doses of the extract significantly elevated plasma cholesterol, triglycerides, creatinine, and glucose levels; however, it did not significantly affect total protein, albumin, and globulin levels. Oxidative stress biomarkers indicated that 0.5%, 1%, and 2% doses were safe, while 5% and 10% extracts induced oxidative stress in fish. In conclusion, lower doses (0.5%–2%) of TPE are recommended for evaluating its therapeutic properties, as they offer safe and effective treatment for common carp without causing oxidative stress.

Source: Aquaculture Research

DOI: 10.1155/are/9920304

Authors: Nezam Armand, Raham Armand, Seyed Mohamad Javad Shokouhian, Kasim Sakran Abass, Hadi Pourjafar

Institutions: Alborz University of Medical Sciences, Islamic Azad University, Karaj, University of Kirkuk

Language: English

Topic: Aquaculture disease management and microbiota

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,700