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Application Value of QRS Wave Potential in Predicting Left Ventricular Remodeling and Adverse Cardiovascular Events in Patients with Acute Myocardial Infarction After PCI

Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective: To investigate whether fragmented QRS (fQRS) on electrocardiogram (ECG) obtained 24-48 hours after percutaneous coronary intervention (PCI) predicts left ventricular remodeling (LVRM) and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI). Methods: A total of 122 AMI patients who underwent PCI were prospectively enrolled and categorized into fQRS (n=48) and non-fQRS (n=74) groups based on post-PCI ECG findings. Clinical data, serum biomarkers, left ventricular function, and the incidence of MACE were compared between groups. Cox proportional hazards regression and logistic regression analyses were used to identify independent predictors of MACE and LVRM, respectively. Results: Patients in the fQRS group exhibited significantly higher levels of cardiac biomarkers (cTnI, CPK, CK-MB), more adverse lipid profiles, and impaired renal function parameters (all P < 0.05). Echocardiographic assessment revealed significantly reduced left ventricular ejection fraction (51.5% vs 57.2%, P < 0.001) and increased wall thickness in the fQRS group. During one-year follow-up, the fQRS group had a substantially higher incidence of MACE (35.4% vs 10.8%, P < 0.001). Multivariate analysis confirmed post-PCI fQRS as an independent predictor for both LVRM (OR: 3.12, 95% CI: 1.48-6.55, P = 0.003) and MACE (HR: 2.65, 95% CI: 1.52-4.63, P = 0.001). Conclusion: fQRS identified on ECG after PCI is a significant independent predictor of LVRM and MACE in AMI patients, providing valuable prognostic information for risk stratification.
DOI: 10.2147/ijgm.s564055
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,836
OpenAlex ID: W7119808100
FWCI:
Cites: 26
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