Work

Simplified synthesis of anti-oxidant small molecule OHPyN3

Year: 2026

Type: article

Abstract: We have designed a short, improved synthetic strategy for the synthesis of a multi-tactical anti-oxidant small macrocycle molecule. The overall simplified 6-step synthetic scheme gave a chemical yield of 45.7% compared to the previously reported strategy of 22.4%. The synthesis of the macrocycle started with esterification of chelidamic acid through a series of reactions, including Richman-Atkins macrocyclization, and ends with global deprotection of compound 6 to obtain the final product.

Source: MethodsX

DOI: 10.1016/j.mex.2026.103950

Authors: David Mingle, Nitish Kumar, Kayla N. Green

Institution: Texas Christian University

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,260

Funders: Welch Foundation, National Institute of General Medical Sciences