Work

At home monitoring of chronic adaptive deep brain stimulation for Parkinson's disease

Year: 2026

Type: article

Abstract: Exaggerated subthalamic nucleus (STN) beta oscillations and synchrony reflect pathological neural activity in Parkinson's disease (PD) and are associated with worsening of motor symptoms [1]. STN open-loop, continuous deep brain stimulation (cDBS) effectively alleviates motor symptoms but does not respond to dynamic fluctuations in pathological neural activity over time. Recent advancements in DBS systems have enabled local field potentials sensing and tracking of relevant neural biomarkers. Embedded control policy algorithms use these to adjust stimulation parameters in real time, known as adaptive deep brain stimulation (aDBS).

Source: Brain stimulation

DOI: 10.1016/j.brs.2026.103028

Authors: Chuyi Cui, Jin Woo Choi, Shreesh Karjagi, Kevin B. Wilkins, Aarushi Negi, Helen M. Bronte-Stewart

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Neurological disorders and treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,430