Work

In silico design of stable single-domain antibodies with high affinity

Year: 2026

Type: article

Source: Structure

DOI: 10.1016/j.str.2025.12.010

Authors: Zhongyao Zhang, Rob van der Kant, Iva Marković, David Vizarraga, Teresa Garcia, Katerina Maragkou, Javier Delgado Blanco, Damiano Cianferoni, Gabriele Orlando, Gabriel Cia, Nick Geukens, Carlo Carolis, Alexander N. Volkov, Savvas N. Savvides, Maarten Dewilde, Joost Schymkowitz, Luis Serrano Pubul, Frederic Rousseau

Institutions: VIB-KU Leuven Center for Brain & Disease Research, VIB.AI, KU Leuven, Vlaams Instituut voor Biotechnologie, Ghent University, VIB-UGent Center for Inflammation Research, Barcelona Institute of Science and Technology, Centre for Genomic Regulation, Vrije Universiteit Brussel, VIB-VUB Center for Structural Biology, Institució Catalana de Recerca i Estudis Avançats, Universitat Pompeu Fabra

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: Fonds Wetenschappelijk Onderzoek, Vlaams Instituut voor Biotechnologie, Ministerio de Ciencia e Innovación, Vlaamse regering

Awards: Rational design of biologics for therapeutic development (FoldCo), G3110895200, G3327512123, G5739843823

OpenAlex ID: W7119949297

FWCI: 9.302

Cites: 40

Cited by: 2

Related to: 10