Work

A cross-sectional exploratory study of rat sarcoma (Ras) activation in non-obese women with and without polycystic ovary syndrome

Year: 2025

Type: article

Abstract: showed a moderate effect size for 3 proteins, of which Vascular endothelial growth factor-A (VEGFA) and EGFR were increased and EGFR1 was decreased in PCOS (all FDR p<0.05). EGFR and VEGF pathways interact closely and when EGFR signaling decreases, VEGFA may increase to maintain angiogenic balance, suggesting that in non-obese PCOS there may be a signal for compensatory angiogenesis in a dysfunctional endothelial environment. See also the graphical abstract(Fig. 1).

Source: EXCLI journal

DOI: 10.17179/excli2025-9005

Authors: Niinuma, Sara Anjum, Habib, Haniya, Takemoto, Ashleigh Suzu-Nishio, Sathyapalan, Thozhukat, Atkin, Stephen L., Butler, Alexandra E.

Language: English

Topic: Ovarian function and disorders

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7119956378

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