Work

Designing the structure of new antibacterial drugs based on cephalothin

Year: 2025

Type: article

Abstract: The article presents a computer-generated modification of cephalothin sodium salt molecules with penicillin. This modification is a new structure with potential antibacterial activity. A correlation was found between pharmacological activity, pharmacokinetic parameters, and toxicological properties and the structure of the compound. The research uses the computer technologies allowing the pharmacological properties of new compounds to be modelled. The authors have proposed new structural modifications of the original molecules with improved beta-lactamase activity indicators.

Source: From Chemistry Towards Technology Step-By-Step

DOI: 10.52957/2782-1900-2025-6-4-90-95

Authors: Daniil Podolsky, David Timofeev, Natalia Atapina, Yulia Budaeva, Polina Sidorenko

Institution: Volgograd State Medical University

Language: English

Topic: Synthesis of β-Lactam Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Ministry of Health of the Russian Federation