The efficacy of Cassia fistula on constipation in chronic kidney disease patients in comparison with lactulose: A randomized clinical trial.
Year: 2026
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Objective: syrup (CFS) on CC in CKD patients. Materials and Methods: weeks to evaluate clinical characteristics according to ROME IV criteria, quality of life (PAC-QOL), and laboratory factor levels. Data were analyzed by SPSS25 using intention to treat viewpoint and by applying the ANCOVA, Repeated measure analysis, T-test and Chi-square test. Results: In the CFS group, defecation frequency per week and daily (primary outcome) improved significantly compared to the lactulose group (p-Value=0.01).As secondary outcomes, the percent of straining, lumpy stools and stool hardness in the CFS group was significantly better than the lactulose (p <0.05). In the CFS group, blood urea nitrogen (BUN) (p-Value=0.045) and creatinine (Cr) (p =0.01) decreased after the intervention significantly. PAC-QOL showed significant improvements in subscales and total scores in the CFS group compared to the lactulose group (p<0.001). Conclusion: This is the first trial that evaluated CFS on CC in CKD patients, and monitored the changes in laboratory factors levels. CFS demonstrates greater efficacy than lactulose in managing CC among CKD patients. PAC-QOL was greatly better in CFS group rather than lactulose group.
Source: PubMed
Institution: Babol University of Medical Sciences
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7119995075