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One-pot dearomatizative telescoped addition of C -nucleophiles to fluorinated 1,2,4-oxadiazoles followed by regioselective N -functionalization

Year: 2026

Type: article

Abstract: The constitutive low aromaticity of easily accessible 5-trifluoromethyl-1,2,4-oxadiazoles is explored to enable editing modification to the corresponding unprecedented gem -disubstituted 1,2,4-oxadiazolines.

Source: Organic Chemistry Frontiers

DOI: 10.1039/d5qo01707f

Authors: Davide Castiglione, Sara Amata, Federica Lauria, Andrea Maranzana, Salvatore Baldino, Alexander Prado-Roller, Laura Castoldi, Antonio Palumbo Piccionello, Vittorio Pace, Eisuke I. Comas Iwasita

Institutions: University of Turin, University of Palermo, University of Vienna, University of Milan, Sapienza University of Rome

Language: English

Topic: Structural and Chemical Analysis of Organic and Inorganic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funder: Austrian Science Fund

Award: G2978994897

OpenAlex ID: W7119996529

FWCI:

Cites: 71

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