Year: 2026
Type: article
Abstract: Understanding neurogenesis, the complex biological process of generating new neurons, is crucial for understanding brain development, function, and potential therapeutic interventions for neurological disorders. Due to the inherent difficulty of directly observing neurogenesis in the human brain, researchers heavily rely on cell models to simulate this process under controlled conditions. These models serve as invaluable tools to understand the mechanisms underlying the different stages of neurogenesis, helping researchers explore how neurons are generated, mature, and integrate into neural networks, thereby contributing to both normal brain function and neurological disorders. Therefore, this work provides a comprehensive overview of different cell models commonly used in neurogenesis research, from primary cultures and stem cells to immortalized cell lines. This compilation highlights the strengths and limitations of each cell model, which ultimately allows researchers to select the most appropriate model system for their research, thus enhancing the efforts towards unraveling the mysteries of the brain.
Source: Journal of Neurochemistry
DOI: 10.1111/jnc.70344
Institution: University of Aveiro
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,330
Awards: Unravelling TRPV2 as a novel promising therapeutic target for Myotonic Dystrophy Type 1, G4751688921, Understanding the contribution of BRI2 processing and phosphorylation for neuronal differentiation: towards a pro-neurogenic therapy for Alzheimer's disease, G7888811294, Decifrar o papel da proteína BRI2 na diferenciação neuronal e os mecanismos moleculares subjacentes rumo a uma terapia regenerativa inovadora para a doença de Alzheimer
OpenAlex ID: W7120176685