Year: 2025
Type: article
Abstract: BACKGROUND: The IWG and AA diagnostic criteria are major references in the Alzheimer's domain. Although they share analogies, some key differences should be recognized. METHOD: The original IWG 2024 JAMA Neurology and AA 2024 Alzheimers Dement papers will be used as the major data references. RESULT: I will outline the similarities and differences between the IWG and the AA criteria for Alzheimer's disease from the point of view of the former. I will discuss similarities regarding: Aim of clinical research on AD and other cognitive disorders, Role of co-pathology, Role of brain reserve, Biomarker use, Indication for anti-β-amyloid, Contra-indication for anti-β-amyloid, and Health care delivery model. I will discuss differences regarding: Core question, Scientific discourse, Knowledge source, Definition of AD, Diagnosis of AD, and Interventions for AD. CONCLUSION: The differences between the two sets of criteria are not "just semantics". A unified definition of AD is essential to advance the field and improve patient care.
Source: Alzheimer s & Dementia
Authors: Clifford R. Jack, Giovanni B. Frisoni
Institutions: Mayo Clinic, University Hospital of Geneva
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
OpenAlex ID: W7120181286
FWCI:
Cites:
Cited by:
Related to: