Work

P-832. MeMed BV in Management of Adults Presenting with COPD Exacerbation to the ED: A Single-Center, Real-World Study

Year: 2026

Type: article

Abstract: Background Distinguishing between bacterial and viral etiologies in emergency department (ED) patients remains a clinical challenge, particularly for COPD exacerbations. MeMed BV® (MMBV) is an FDA-cleared host-protein test that provides a score (0-100) indicating bacterial (or bacterial co-infection) versus viral (or other non-bacterial) infections, with sensitivity and specificity >90%. This study examined MMBV’s integration into routine ED workflows for COPD exacerbations. Methods A single center, real-world study, where MMBV was incorporated into ED guidelines for managing adult patients with COPD exacerbation. Clinicians were trained to consider MMBV scores as: < 35 (viral/other non-bacterial), 35–65 (equivocal), and >65 (bacterial or co-infection). In this preliminary analysis (April-September 2024), inclusion criteria were COPD diagnosis, age ≥18 and ED presentation with respiratory complaints. Main exclusion criteria were trauma or non-COPD-related exacerbations. Data were prospectively collected on patient demographics, medical history, lab results, treatment course, hospitalization, and ED revisits (within 7-days). MMBV concordance was defined as not prescribing antibiotics for viral results and prescribing antibiotics for bacterial results. Outcomes were analyzed separately for admitted and discharged patients. Results Analysis included 128 patients (median age 71, IQR: 59–83), with 79.7% aged ≥65 and 32.0% female. MMBV results were bacterial in 60 (46.5%) patients, equivocal in 26 (20.1%), and viral in 43 (33.3%). Twenty-two patients (17.1%) were discharged from the ED: 3 had bacterial results (all prescribed antibiotics), 6 had equivocal and 13 had viral results (none prescribed antibiotics); representing 100% MMBV concordance. None of the patients with non-equivocal MMBV results had unplanned ED revisits. Among 106 admitted patients, 57 had bacterial results (70.2% received antibiotics), 20 had equivocal results (40.0% received antibiotics), and 29 had viral results (17.2% received antibiotics); representing 75.3% MMBV concordance. Conclusion Incorporating MMBV into routine ED care for COPD exacerbations is associated with targeted antibiotic use and safe discharges. Disclosures Tanya Gottlieb, PhD, MeMed Diagnostic: Employee

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofaf695.1040

Authors: Eli Audi, Tanya Gottlieb, Asala Abu-Ahmad, Mirit Hershman-Sarafov

Institutions: Technion – Israel Institute of Technology, Bnai Zion Medical Center

Language: English

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,053