Work

Design, synthesis and evaluation of new pyrazino[1′,2′:1,5]pyrrolo[2,3- d ]pyrimidines as tacrine-like acetylcholinesterase inhibitors

Year: 2026

Type: article

Abstract: A series of eighteen pyrazino[1′,2′:1,5]pyrrolo[2,3- d ]pyrimidine derivatives were designed and synthesized as novel tacrine-like AChE inhibitors.

Source: RSC Advances

DOI: 10.1039/d5ra06700f

Authors: Liubov V. Muzychka, Oksana V. Muzychka, Oleksandr L. Kobzar, Andriy I. Vovk, Oleg B. Smolii

Institution: Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar

Language: English

Topic: Cholinesterase and Neurodegenerative Diseases

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042

Funder: National Academy of Sciences of Ukraine

Awards: G1265343130, G996415560

OpenAlex ID: W7122480867

FWCI: 3.89

Cites: 59

Cited by: 1

Related to: