Year: 2026
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide The conversion of carbon dioxide into value-added products has emerged as an alternative method to achieve net-zero emissions. While technologies that transform CO 2 into fuels and chemical feedstocks have made great strides, the direct use of CO 2 as a C1 synthon for the formation of new carbon–carbon bonds remains a critical challenge. Herein, we present a new catalytic CO 2 activation mode for hydrocarboxylation reactions. Key to this methodology is the formation of a CO 2 carbamate with a phenothiazine catalyst, which sets the required trigonal geometry for the release of CO 2 •– via photolysis upon absorption of visible light. The polarity-reversed CO 2 •– is employed in the hydrocarboxylation reactions of alkenes and heterocycles. This protocol is distinguished by its mild reaction conditions, wide substrate scope and broad applicability, even in the context of pharmaceutical cores. Our chemistry can also be utilized for the synthesis of carbon-13 labeled spirolactones using 13 CO 2 . Mechanistic experiments support the photolysis of the CO 2 carbamate as the main productive pathway under our optimized reaction conditions.
DOI: 10.1021/jacs.5c21208
Language: English
Subfield: Process Chemistry and Technology
Field: Chemical Engineering
Domain: Physical Sciences
SDG: Climate action
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W7122588156