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Clinical Efficacy of Traditional Chinese Medicine Chaihu‐Guizhi‐Ganjiang Decoction Combined With Danggui‐Shaoyao‐San for the Treatment of Oligomenorrhea: A Prospective, Open‐Label Clinical Study

Year: 2026

Type: article

Abstract: Objective To assess the efficacy and safety of Chaihu‐Guizhi‐Ganjiang decoction (CGGJD) combined with Danggui‐Shaoyao‐San (DS) in oligomenorrhea treatment. Methods In this prospective open‐label trial, 35 oligomenorrhea patients (30–40 years) received CGGJD‐DS for 3 months, followed by a 2‐month follow‐up. Outcomes included clinical efficacy rate, menstrual pattern and frequency, serum hormones (E2, LH, and FSH), uterine spiral artery indices (RI, PI, and S/D), endometrial blood flow parameters (VI, FI, and VFI), and endometrial thickness assessed pre‐/post‐treatment and post–follow‐up. Results Post‐treatment menstrual pattern and frequency both significantly increased versus baseline ( p < 0.01), with a 68.6% total efficacy rate. E2 levels significantly increased post‐treatment and post–follow‐up (both p < 0.01), while LH and FSH decreased significantly (both p < 0.01). Significant improvements occurred in spiral artery indices (all p < 0.01), endometrial blood flow parameters (all p < 0.01), endometrial blood distribution (Wald χ 2 = 20.8, p < 0.01), and endometrial thickness ( p < 0.01). No serious adverse events occurred. Conclusions CGGJD‐DS effectively improves ovarian function and endometrial perfusion in oligomenorrhea, demonstrating potential as an alternative therapy.

Source: International Journal of Clinical Practice

DOI: 10.1155/ijcp/8431842

Authors: Mei Yu, Gui-Yan Liu, Wen-Xuan Zhou, Zhao-Hua Liu, Lian-Tao Li

Institutions: Guangzhou University of Chinese Medicine, Shandong University

Language: English

Topic: Menstrual Health and Disorders

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,350