Work

Hydrogen-bond-assisted meta-nitrogen-doped graphyne enables real-time electrocatalytic NADH tracking in single cells

Year: 2026

Type: article

Abstract: MPP + drives α-synuclein to cluster, Ca 2+ to surge and mPTP to open, triggering NADH release. 3NGYO/CFNE senses NADH through N–H⋯OP bonds for real-time reporting of mitochondrial failure and neurodegeneration.

Source: Chemical Science

DOI: 10.1039/d5sc08242k

Authors: Jiale Wei, Jing Jiang, Chuqi Li, Guo Wang, Jiayao Wulan, Huan Yang, Fangxu Shen, Daixin Ye, Kai Li, Xianchan Li, Yuqing Lin

Institutions: Capital Normal University, Peking University, State Key Laboratory of Natural and Biomimetic Drugs, Shanghai University

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Recruitment Program of Global Experts, Beijing Municipal Natural Science Foundation, National Key Research and Development Program of China

Awards: 基于流体忆阻器的类脑感知原理、材料与器件性能研究, G3514638388, G5828795962, G6488914470, G6961219835

OpenAlex ID: W7122622416

FWCI: 3.531

Cites: 85

Cited by: 2

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