Year: 2026
Type: article
Abstract: We found that healthy mice harbor T cells with heritable low Pten expression and that monoallelic Pten loss in CD4 T cells causes a bias in their differentiation toward T follicular helper cells during acute viral infection. These results suggest that somatically induced mono- or biallelic loss of expression of signaling-related genes in T cells can impact the quality of population-level T cell responses-without conspicuous pathological sequelae such as autoimmune and inflammatory manifestations or lymphomagenesis.
Source: Scientific Reports
Authors: Allen Y. Chen, Alexander Y. Rudensky
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funders: Memorial Sloan-Kettering Cancer Center, Hospital for Special Surgery, Cycle for Survival, York University, National Institutes of Health, School of Medicine, New York University, Ludwig Center at Harvard, Marie-Josée and Henry R. Kravis Center for Molecular Oncology, National Cancer Institute
OpenAlex ID: W7122728685