Work

PROTACs for Collateral Degradation: Is It Time to Back Up the Bus?

Year: 2026

Type: article

Abstract: Off-target effects are usually undesirable in drug development, but for some PROTACs and other degraders, they may be advantageous. Specifically, this can be so when the activities of multiprotein complexes are more important than just the targeted protein of interest.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.5c00645

Authors: Zhe Gavin Gao, Kevin Burgess

Institution: Texas A&M University

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500