Work

Clinical complete response achieved in patients with breast cancer liver metastasis after personalized treatment: a case report and literature review

Year: 2026

Type: article

Abstract: Patient-derived organoids (PDOs) have been demonstrated not only to predict the response to neoadjuvant chemotherapy but also to tailor the treatment options for advanced breast cancer to improve prognosis. Here, we first reported a case of breast cancer liver metastasis that obtained clinical complete response (cCR) after treatment with eribulin and capecitabine, which showed sensitivity in the organoid drug sensitivity testing, and we conducted a systematic literature review. Our case report further provides a scientific basis for the PDOs as a powerful preclinical model to predict individual treatment sensitivity and improve the treatment outcomes of patients with advanced breast cancer, especially those with refractory or heavily treated breast cancer.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2025.1546691

Authors: Yuxiang Wang, Yuxiang Wang, Na Jing, Yu Wang, Yu Wang, Ning Li

Institutions: Shanxi Medical University, Chinese Academy of Medical Sciences & Peking Union Medical College, Shanxi Provincial Cancer Hospital

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801