Work

Association of medication regimen complexity index with ADRs in HIV/AIDS patients: a retrospective cohort study

Year: 2026

Type: article

Abstract: Purpose: To investigate the correlation between the medication regimen complexity index (MRCI) and adverse drug reactions (ADRs) among acquired immunodeficiency syndrome (AIDS) patients in the Chinese population. Introduction: The complexity of antiretroviral therapy (ART) regimens in individuals living with human immunodeficiency virus (HIV) presents significant challenges to medication management. To date, no studies have investigated the correlation between the MRCI and ADRs. Methods: This study retrospectively enrolled 1,010 patients. The MRCI was utilized to quantify the complexity of pharmacological treatment regimens. All suspected ADRs were assessed for causality using the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) system. Univariate and multivariate logistic regression analyses were conducted to identify risk factors associated with ADRs and MRCI. Results: = 0.036) emerged as independent risk factors for adverse reactions in HIV/AIDS patients. Conclusion: In China, the MRCI of HIV/AIDS patients significantly increased after hospitalization. Further analysis indicates that patients with higher MRCI are more likely to experience ADRs.

Source: Frontiers in Pharmacology

DOI: 10.3389/fphar.2025.1721289