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Factors regarding blood donation willingness and preferences toward feedback between first-time donors and repeat donors in China: a cross-sectional survey

Year: 2026

Type: article

Abstract: Background Identifying the factors associated with blood donation willingness and preferences for feedback enables more effective strategic recruitment planning to promote the expansion of the donor pool. Objective To determine the difference of factors influencing willingness of donation between first-time and repeat donors. Methods A multi-center cross-sectional study was conducted across three Chinese cities, namely, Nanjing, Zhenjiang, Danyang from December 2023 to June 2024. Participants were recruited through Jiangsu Provincial Blood Center. Data were collected via self-administered online questionnaires included demographic information, willingness to donate blood, and knowledge about blood donation. Factors influencing donation willingness were identified using multivariate logistic regression analyses. Results A total of 1,385 participants were included in final analysis, comprising 320 first-time donors and 1,065 repeat donors. After adjustment for potential confounders, high-volume donation history was associated with greater re-donation willingness than low-volume history [adjusted odds ratio (aOR) = 4.66; 95% confidence interval (CI): 2.21–9.85; p < 0.001]. Donors with long-term residency also demonstrated higher interest for repeat donation compared to non-permanent residents (aOR = 2.29; 95% CI: 1.55–3.39; p < 0.001). Additionally, comprehensive knowledge of donation contributes to enhanced willingness for repeat participation (aOR = 8.76; 95% CI: 3.24–23.66; p < 0.001). Donors hold personal motivation (aOR = 2.00; 95% CI: 1.40–2.86; p < 0.001), incentive provision (aOR = 3.33; 95% CI: 1.32–8.41; p = 0.011), and positive environmental experiences (aOR = 2.51; 95% CI: 1.19–5.53; p = 0.016) constituted significant factors enhancing re-donation willingness. Moreover, increasing incentive value (aOR = 1.70; 95% CI: 1.06–2.73; p = 0.029) and offering vaccination chance (aOR = 1.66; 95% CI: 1.06–2.61; p = 0.028) as the preferences for feedback were associated with re-donation interest. Conversely, reduced willingness correlated with adverse event experiences (aOR = 0.49; 95% CI: 0.34–0.71; p < 0.001) and certificate issuance (aOR = 0.60; 95% CI: 0.42–0.84; p = 0.003). Conclusions The factors influencing willingness differ significantly between first-time and repeat blood donors. Interventions should prioritize strengthening and disseminating knowledge among first-time donors to attract potential new donors. For repeat donors, enhancing the experience and implementing favorable policies are recommended to maintain donor pool. These targeted strategies would enhance donation rates in the future by governmental support.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1730038