Work

Platelet membrane-camouflaged matrine biomimetic nanoparticles for efficient acute lung injury therapy

Year: 2026

Type: article

Abstract: . In an ALI mouse model, PM@Mat-NPs selectively accumulated in inflamed lung tissue, significantly reduced pro-inflammatory cytokines (TNF-α, IL-6), and alleviated histological damage. They also suppressed NLRP3 inflammasome activation and apoptosis, outperforming free matrine. Biosafety evaluations confirmed no significant adverse effects. This study introduces a biomimetic nano-platform for the targeted delivery of Chinese herbal components, offering a promising strategy for treating acute lung injury.

Source: iScience

DOI: 10.1016/j.isci.2026.114683