Year: 2026
Type: article
Abstract: Nitisinone, a systemic inhibitor of tyrosine catabolism, has recently emerged as a promising endectocide with demonstrated lethality against mosquitoes and tsetse flies. To assess its efficacy against Lutzomyia longipalpis, an important vector of Leishmania infantum -the causative agent of zoonotic visceral leishmaniasis prevalent in the Mediterranean basin, Latin America, and parts of the Middle East-, we exposed sand flies to a concentration previously shown to be lethal to Anopheles mosquitoes (250 ng/mL). Survival was monitored over 14 days and showed no significant difference between treated and control groups, indicating a lack of insecticidal effect at this dose. These findings suggest that Lu. longipalpis exhibits tolerance to nitisinone, likely due to species-specific metabolic differences. Although nitisinone remains a promising tool for systemic vector control, its effectiveness against sand flies may require higher doses or alternative compounds.
Source: PLoS neglected tropical diseases
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,670
OpenAlex ID: W7123347323