Work

Specific Patterns of CD39 Expression on T-cells of HIV/HCV Coinfected Patients Receiving Antiretroviral Therapy: A Case-control Study

Year: 2026

Type: article

Abstract: Human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfection leads to severe systemic inflammation, increasing non-AIDS morbidity and mortality risk. CD39 ectoenzyme on T-cells, which catalyzes the conversion of pro-inflammatory purines to immunosuppressive adenosine, plays an important role in inflammation control. The role of CD39+ T-cells in systemic inflammation during HIV/HCV coinfection under antiretroviral therapy (ART) remains unexplored. This study aimed to identify specific patterns of CD39 expression on T-cells in ART-treated HIV/HCV coinfected patients and assess their relationship with systemic inflammation.

Source: Gene Expression

DOI: 10.14218/ge.2025.00065

Authors: Evgeniya Saidakova, Larisa Korolevskaya, Violetta Vlasova

Institutions: Ural Branch of the Russian Academy of Sciences, Institute of Ecology and Genetics of Microorganisms, Russian Academy of Sciences

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Ural Branch, Russian Academy of Sciences