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Somatic malignant transformation of teratoma in children and adolescents - Case series with literature review

Year: 2026

Type: article

Abstract: Somatic malignant transformation (SMT) is defined as the development of non germ cell malignant neoplasm within a teratoma. Malignant change can occur in any of the various components of the three germ cell layers. In adults, more than 80 % of all malignant transformations are squamous cell carcinoma, the rest being adenocarcinoma and carcinoid tumor. In children, SMT are very uncommon and reports are limited. We report a case series of three children who presented with SMT of a teratoma. We also undertook a literature search of published reports on SMT in children.

Source: Pediatric Hematology Oncology Journal

DOI: 10.1016/j.phoj.2025.100800

Authors: Yamini Krishnan, Smitha Bhaskaran, Venma Jojo, Pavitra Subramanian, S. Gazel, V.P. Krishnan

Language: English

Topic: Teratomas and Epidermoid Cysts

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600

OpenAlex ID: W7123353896

FWCI:

Cites: 20

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