Work

Analysis of risk factors and development of a predictive model for IABP application in post-cardiac valve replacement patients

Year: 2026

Type: article

Abstract: Objective To identify risk factors for intra-aortic balloon pump (IABP) requirement following heart valve replacement surgery (HVRS) and to develop a predictive model. Methods This retrospective cohort study analyzed 161 HVRS patients (October 2023 to January 2025) from the First Affiliated Hospital of Xinjiang Medical University. Patients were stratified into IABP ( n = 58) and non-IABP ( n = 103) groups. Independent risk factors were identified through univariate analysis, LASSO regression, and multivariate logistic regression. The cohort was randomly split into training and validation sets (7:3 ratio) for model development and internal validation. Model performance was assessed using receiver operating characteristic (ROC) curves, Hosmer-Lemeshow calibration, and decision curve analysis (DCA). Results Significant differences were observed between groups across multiple parameters (all P < 0.05), including demographics, inflammatory markers, cardiac biomarkers, and echocardiographic indices. Multivariate analysis identified five independent risk factors for postoperative IABP use: age (OR = 1.138, 95% CI: 1.067–1.226), stroke volume (SV) (OR = 1.155, 95% CI: 1.060–1.296), cardiac output (CO) (OR = 5.700, 95% CI: 2.700–12.040), cardiac index (CI) (OR = 4.982, 95% CI: 2.879–10.119), and left ventricular end-systolic diameter (LVESD) (OR = 1.463, 95% CI: 1.157–1.849). The prediction model showed excellent discrimination in both the training set (AUC = 0.946, 95% CI: 0.910–0.982) and the validation set (AUC = 0.933, 95% CI: 0.876–0.990). Good calibration was indicated by Hosmer-Lemeshow test ( P > 0.05 for both sets), and decision curve analysis confirmed the model's clinical utility. Conclusion A model incorporating five routinely available preoperative variables effectively stratifies the risk of requiring IABP after HVRS, demonstrating strong discriminatory performance and potential clinical applicability for preoperative risk assessment.

Source: Frontiers in Surgery

DOI: 10.3389/fsurg.2025.1728752

Authors: Rukeya Hashan, Wang Zhengkai

Institutions: Xinjiang Medical University, First Affiliated Hospital of Xinjiang Medical University

Language: English

Topic: Mechanical Circulatory Support Devices

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801