Work

The relationship between axial length and anterior segment biometry in high axial myopic Chinese students aged 7 to 18 years

Year: 2026

Type: article

Abstract: Purpose This study aimed to examine the relationship between axial length (AL) and anterior segment biometry in Chinese children and adolescents with high axial myopia. Methods A cross-sectional study was conducted involving 366,278 Chinese students aged 7 to 18 years from January 2020 to December 2022. The SUOER μ -Meter optical biometric was used for measuring ocular biometric parameters. A multivariate linear regression model was used to examine the correlation with AL. Results Among the participants, 28,877 exhibited high axial myopia (AL ≥ 26 mm). The average keratometry (K) and lens thickness (LT) in the high axial myopia group were significantly lower than those in both the non-myopia and normal myopia groups (all p < 0.001). Central corneal thickness (CCT) and anterior chamber depth (ACD) were significantly greater in the high axial myopia group compared to both non-myopia and normal myopia groups (all p < 0.001). Multivariate linear regression analysis demonstrated that K ( β = −0.265), CCT ( β = 0.001), ACD ( β = 1.609), and LT ( β = −0.607) were all correlated with AL (all p < 0.001). After adjusting for gender and age, when AL was <27 mm, AL was negatively correlated with LT; similarly, when AL exceeded 27 mm, there was no linear correlation between AL and LT ( p > 0.05). Conclusion In Chinese children and adolescents, a high AL (i.e., ≥26 mm) was associated with significantly lower K, thicker CCT, and deeper ACD, and thinner LT compared with subjects having AL < 26 mm. When AL was <27 mm, LT thinning may contribute to myopia compensation; however, when AL exceeds 27 mm, this compensatory effect of crystalline lens thickness appears to diminish.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1671451

Authors: Zengrui Zhang, Jingyu Mu, Yanrong Yang, Yun Dai, Junguo Duan

Institutions: Chengdu University, Chengdu University of Traditional Chinese Medicine

Language: English

Topic: Ophthalmology and Visual Impairment Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801