Work

Case Report: Nebulized platelet-rich plasma facilitates resolution of post-infective pulmonary consolidation and cavitation in a lung cancer survivor

Year: 2026

Type: article

Abstract: Background: Persistent lung consolidation and cavitary lesions are recognized sequelae of severe pneumonia, particularly in patients with prior oncologic or radiation-related lung injury. Platelet-rich plasma (PRP) contains growth factors and cytokines that promote tissue repair and immune modulation, yet its pulmonary application remains largely unexplored. Case presentation: A woman in her mid-40s with a history of stage IV right-lower-lobe non-small-cell lung cancer (NSCLC) in long-term remission developed severe pneumonia while overseas. Six weeks after discharge, a low-dose CT revealed persistent right-upper-lobe consolidation with internal lucency. She administered nebulized autologous PRP for 4 weeks using a compressor-based nebulizer. Results: Serial CT imaging demonstrated rapid reduction and eventual resolution of the consolidation with closure of a cavitary defect. The patient experienced no bronchial irritation or adverse effects. Conclusion: Nebulized autologous PRP was temporally associated with radiologic resolution of a post-infective cavitary lesion in a previously irradiated lung. This finding supports further study of PRP's regenerative potential in pulmonary disease.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1738044

Authors: Zane Sherif, Kirralee Sherif

Institution: Mermaid Beach Radiology

Language: English

Topic: Periodontal Regeneration and Treatments

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801