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Increased prevalence of autoantibodies neutralizing IFNλ2/3 in young individuals with cystic fibrosis

Year: 2025

Type: article

Abstract: Groen et al. identify neutralizing interferon-λ2/3 autoantibodies in 11.8% of individuals with cystic fibrosis, a greater than 10-fold higher prevalence than in control individuals. Autoantibody-containing plasmas enhanced respiratory virus replication in vitro, and associated with allergic rhinitis in patients, suggesting that interferon-λ2/3 autoantibodies have the potential to impact mucosal pathology.

Source: Journal of Human Immunity

DOI: 10.70962/jhi.20250268