Work

Case Report: Luspatercept for transfusion-dependent anemia of unknown etiology

Year: 2026

Type: article

Abstract: Anemia is a common clinical problem with diverse etiologies. Transfusion-dependent anemia (TDA), defined by the need for frequent red blood cell transfusions, can arise from various hematologic disorders. However, in rare instances, despite extensive diagnostic evaluation, the underlying cause may remain elusive. We present a case of a young woman with severe, transfusion-dependent anemia of unknown etiology who failed multiple therapeutic strategies but achieved transfusion independence following treatment with luspatercept. This case highlights the potential for off-label use of luspatercept beyond currently approved indications.

Source: Frontiers in Hematology

DOI: 10.3389/frhem.2025.1714544

Authors: Simran Chandra, Vasu Bansal, Parth Sharma, Furha Cossor

Institutions: University of Missouri, Virginia Commonwealth University, Saint Luke's Hospital

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,353