Work

Biosynthesis of polyamine-polyphosphate granules for colitis alleviation

Year: 2026

Type: article

Abstract: . Notably, the oral administration of PPGs increased colonic polyamine levels, alleviated DSS-induced colitis, reduced inflammatory cytokines, and restored gut microbiota balance. Overall, biosynthesized PPGs represent a highly promising material for mitigating colitis.

Source: iScience

DOI: 10.1016/j.isci.2026.114679

Authors: Zihao Fan, Xuena Zhang, Xiaotong Ge, Lei Zhu, Minsheng Zhu, Liuyan Yang

Institutions: Model Animal Research Center, Nanjing University, Nanjing Drum Tower Hospital, Nanjing Agricultural University

Language: English

Topic: Polyamine Metabolism and Applications

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240