Changes in Sero-immunological Status for Infectious Diseases in Solid Organ Transplantation: A 20-Year Single-Center Study in Korea
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: With increasing solid organ transplantations (SOTs), updated sero-immunological data are essential, as immune profiles shift across generations and influence preventive strategies. We aimed to evaluate the current sero-immunological status of SOT recipients in Korea. Methods: We retrospectively analyzed pre-transplant sero-immunological test results for 12 infectious diseases from SOT recipients and donors at a single center over 20 yrs. All serological test results obtained during pre-transplant evaluations were included; identical results from repeat tests conducted within 1 yr were excluded. Temporal trends in seropositivity were assessed based on test year, age at testing, and birth cohort. Results: <0.001) demonstrated significant age-dependent declines across SOT recipients. Conclusions: The sero-immunological landscape of SOT candidates has changed over time, reflecting generational shifts in Korean society. These changes highlight the importance of targeted screening and tailored management, particularly for high-risk donor-seropositive/recipient-seronegative transplantations, as well as the critical need for timely immunization in transplant candidates.
Source: Annals of Laboratory Medicine
Institutions: Samsung Medical Center, Sungkyunkwan University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7123362203