Year: 2026
Type: article
Study design: Case Report
Abstract: Transverse myelitis (TM) is an inflammatory disorder of the spinal cord characterized by motor, sensory, and autonomic impairments. Parainfectious transverse myelitis (PITM) represents a post-infectious, immune-mediated entity. Its occurrence during pregnancy is rare and presents with unique diagnostic and therapeutic challenges. We report a 31-year-old primigravida at 32 weeks of gestation who presented with acute-onset bilateral lower limb weakness, sensory loss, and bladder involvement following a febrile illness. MRI spine revealed longitudinally extensive transverse myelitis (C3-T2). The cerebrospinal fluid analysis showed lymphocytic pleocytosis with a negative infectious and autoimmune work-up. She was treated with intravenous methylprednisolone, which was followed by intravenous immunoglobulin (2 g/kg over five days), with a gradual neurological recovery. She subsequently developed urinary sepsis at 35 weeks and underwent emergency cesarean section, delivering a preterm infant. At two months postpartum, she had near-complete motor recovery with only mild bladder urgency. While PITM in pregnancy is rare, it is potentially reversible with timely immunomodulatory therapy. Intravenous immunoglobulin may be considered as a safe and effective adjunct to corticosteroids in selected cases.
Source: Cureus
Authors: Akshatha Hegde, Akshatha V Rai, Anirudh Shetty
Institutions: Manipal Hospital, K.S. Hegde Hospital, Narayana Health
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7123362397