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Research progress on traditional Chinese medicine in treating autoimmune thyroiditis by targeting NLRP3 inflammasome

Year: 2025

Type: article

Abstract: Recent studies have revealed that the NLRP3 inflammasome is involved in the pathogenesis of autoimmune thyroiditis (AIT) by regulating inflammatory response， pyroptosis， oxidative stress， and immune homeostasis.Traditional Chinese medicine (TCM) inhibits NLRP3 inflammasome activation through multi-component and multi-target mechanisms， demonstrating unique therapeutic potential.This article systematically reviews the role of the NLRP3 inflammasome in AIT and the research progress of TCM intervention， thus providing some new ideas for clinical therapy.

Source: Lishizhen Medicine and Materia Medica Research

DOI: 10.70976/j.1008-0805.szgygy-2025-2319

Authors: Lili ZHANG, Dongpeng ZHANG, Yuanyuan FENG, Jing QU, Zhaohui MA, Lijun DONG, Shouying LIN, Lili LI, Li WANG, Wenwen SUN, Liangxia ZHANG

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7123362634

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