Work

Taraxacum officinale Seed Extract Inhibits HeLa Cell Migration at Sub-cytotoxic Concentrations

Year: 2025

Type: article

Abstract: Dandelion seed extract exhibits potent anticancer activity in HeLa cells. HeLa viability decreased with increasing doses of DSE from 0 to 0.8 mg/mL, while HDF viability was not affected under similar conditions. DSE reduced HeLa cells' migration speed between 0-0.050 mg/mL, while no significant effect was observed in HDF cells over the same range. Both cell lines exhibited a significant decrease in cell migration speed at 0.1 mg/mL. This data suggests that DSE treatment inhibits cell migration before it significantly reduces cell viability. It points to a specific anti-migratory effect independent of viability loss.

Source: PubMed

DOI: 10.17912/micropub.biology.001900

Authors: Christina Hendrickson, Melville B. Vaughan, John Nail, Jeremy Dry

Language: English

Topic: Medicinal Plant Research

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health

Award: Oklahoma IDeA Network of Biomedical Research Excellence