Work

g(E)-pHLIP promote virus Immunity to destroy Cervical Cancer Cell

Year: 2026

Type: article

Abstract: BACKGROUND: Cervical cancer treatment faces challenges in identifying specific targets within heterogeneous tumors. Current antitumor immunotherapy for cervical cancer is constrained by the lack of corresponding therapeutic targets. METHODS: We developed glycoprotein E (gE)-pHLIP nanomicelles, an antigen-targeting peptide particle anchored on cell membranes. This system enables tumor-targeted antigen release, labels tumor tissues, and leverages pre-existing immune responses for tumor elimination by "disguising" cancer cells as viral invaders. RESULTS: In animal models, pre-immunization with g(E) combined with g(E)-pHLIP treatment demonstrated suppressed tumor growth. Reduced tumor recurrence was observed post-treatment. The system successfully activated the body's antiviral immune response against labeled tumor cells. CONCLUSIONS: This study developed a novel protein-peptide system that labels cervical cancer cells, "disguises" them as viral invaders to the body, and subsequently eliminates tumors through the body's antiviral immune response.

Source: European journal of medical research

DOI: 10.1186/s40001-025-03787-7

Authors: Zhangguo Ying, Mengmeng Shi, Wangang Gong, Yujie Chen, Guangyi Jiang

Institutions: Wenzhou Medical University, Hangzhou Normal University, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190