Work

Amlodipine: Guardian or Provocateur? Exploring Its Role in Parkinsonism

Year: 2025

Type: article

Abstract: Drug-induced parkinsonism (DIP) is a debilitating side effect associated with several classes of medications. Amlodipine is a widely used dihydropyridine calcium channel blocker (CCB) commonly prescribed for hypertension and angina. We present a case of a 62-year-old man who underwent liver transplantation and developed parkinsonism shortly after initiation of amlodipine for hypertension. After ruling out other causes for his neurological presentation, discontinuation of amlodipine resulted in a rapid improvement of symptoms, confirming the diagnosis of DIP. This report highlights the importance of recognizing amlodipine as a potential cause of new onset parkinsonism and underscores the need for further research to understand its effects on the dopaminergic pathway.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18213202

Authors: Vansh Gulati, Elizabeth Beyene, Leon Seymour, Samrawit Zinabu, Ayushi Sen, Martin Borissov, Syed Fahad Gillan, Girma Ayale, Mekdem Bisrat, Miriam Michael

Institutions: American University of Antigua, Howard University, University of Maryland, Baltimore

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7123439262

FWCI:

Cites:

Cited by:

Related to: