Year: 2026
Type: article
Abstract: BACKGROUND: Amyloidosis is formed following deposition of protein aggregates and is classified by systemic or cutaneous deposition. SUMMARY: These aggregates can be distributed in different organs such as the heart, liver, lungs, kidneys, and skin. Primary cutaneous amyloidosis has been classified into three groups: macular, lichen, and nodular, the former two being one often overlapping process, and the latter a localized plasma dyscrasia with a small risk of representing a systemic disease. KEY MESSAGES: Historically, cutaneous amyloidosis has been misdiagnosed, and most treatment regimens have been ineffective or only provide supportive management, such as decreasing pruritus. The current standard of care, high-potency corticosteroids, can provide symptomatic relief. Newer therapies may decrease amyloid deposition and progression of disease.
Source: Dermatology
DOI: 10.1159/000550263
Authors: Rucha Janodia, Robert A. Schwartz
Institution: Rutgers New Jersey Medical School
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W7123492341