Rarity of silent progression: PIRA and RAW in myelin oligodendrocyte glycoprotein antibody–associated disease
Year: 2026
Type: article
Study design: Observational Study
Abstract: In myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), disability is typically attack-related and frequently remain stable over time if no relapses occur. This retrospective cohort study assessed the prevalence of progression independent of relapse activity (PIRA) and relapse-associated worsening (RAW) in Korean patients with MOGAD from five referral centers. Among 205 patients, 116 with ⩾1 year of follow-up and a minimum of 3 documented EDSS scores were eligible for inclusion. Over a mean follow-up of 62.2 months, PIRA occurred in two patients (1.7%) and RAW in six patients (5.2%), highlighting that PIRA is a rare and atypical event in MOGAD.
Source: Multiple Sclerosis Journal
Institutions: Yonsei University, Severance Hospital, Yonsei University Health System, Chonnam National University, Chonnam National University Hospital, National Cancer Center, National Cancer Center Hospital, The Catholic University of Korea Seoul St. Mary's Hospital, Catholic University of Korea, Kyung Hee University, Kyung Hee University Medical Center
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,400
OpenAlex ID: W7123593720