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Unicentric Castleman Disease of the Mesentery Mimicking a Gastrointestinal Stromal Tumor: A Case Report

Year: 2026

Type: article

Abstract: Unicentric Castleman disease (UCD) is a rare benign lymphoproliferative disorder commonly found in the mediastinum and retroperitoneum, with mesenteric involvement being exceptionally uncommon. We present a case of a 21-year-old male with a history of constipation, fatigue, and recurrent right iliac fossa pain for six months. Initial imaging suggested a gastrointestinal stromal tumor (GIST); however, the final diagnosis of UCD hyaline vascular (HV) variant was made based on immunohistochemical (IHC) analysis and histopathological reports. Surgical excision led to complete resolution of symptoms. This unique case makes UCD a differential diagnosis for a right iliac fossa highly vascular mass and underlines the necessity for comprehensive histological and IHC analysis. Successful surgical intervention and exclusion of multicentric Castleman disease (MCD) have resulted in a favorable patient outcome.

Source: Cureus

DOI: 10.7759/cureus.101485

Authors: Ravi Gupta, Jagani Harsha Sai, Vishakha Gupta, Aditya Gaurav, Santhosh Reddy

Institutions: All India Institute of Medical Sciences Gorakhpur, Sanjay Gandhi Post Graduate Institute of Medical Sciences

Language: English

Topic: Lymphadenopathy Diagnosis and Analysis

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7123596358