Work

Ocular Risks of Spaceflight and a Path to Prevention: Targeting Mitochondria– ER Stress With Low‐Intensity Ultrasound

Year: 2026

Type: article

Abstract: The cornea is highly susceptible to spaceflight-induced stress, compromising visual acuity and mission safety. Here, we identify endoplasmic reticulum (ER) and mitochondrial dysfunction as key mediators of corneal degeneration under simulated microgravity (SMG). SMG exposure led to corneal epithelial thinning, reduced nerve fiber density, and delayed wound healing. Multi-omics profiling and cellular assays revealed aberrant ER-mitochondrial crosstalk, characterized by excessive formation of mitochondria-associated membranes (MAMs) and activation of stress signaling pathways. Notably, treatment with low-intensity ultrasound (LIUS) restored corneal epithelial integrity by modulating MAM dynamics, alleviating organelle stress, and normalizing cellular homeostasis. These findings identify a novel molecular axis in microgravity-induced ocular degeneration and propose LIUS as a deployable, non-invasive countermeasure for preserving corneal health during deep spaceflight.

Source: The FASEB Journal

DOI: 10.1096/fj.202502831rr

Authors: Jee Hoon Lee, Hankyung Kim, Dae Yu Kim

Institution: Inha University

Language: English

Topic: Spaceflight effects on biology

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,740