Work

Prevalence and early-life risk factors of asthma in preterm adolescents: a cohort study

Year: 2026

Type: article

Abstract: Aim: We seek to elucidate the prevalence, types of respiratory symptoms experienced, and potential early-life risk factors of asthma in adolescence. Methods: We performed a prospective cohort study including 294 adolescents [130 moderately-late preterm (MLP), 81 early preterm (EP), and 83 full-term (FT)]. Asthma, asthma-like symptoms, and smoking in early childhood and adolescence were self-reported. We collected prenatal and postnatal characteristics, including maternal smoking, bronchopulmonary dysplasia, and respiratory syncytial virus (RSV) infections. Results: In 11% of EP, 4% of MLP, and 4% of FT adolescents, a formal asthma diagnosis was made. Asthma-like symptoms were reported in 14%, 14%, and 7% of the cases, respectively. Being hospitalized for an RSV infection was associated with a four times higher risk of asthma in adolescence (odds ratio 3.68 and 95% confidence interval 1.04-13.0), while other predictors did not contribute. Conclusion: MLP adolescents have similar rates of asthma and asthma-like symptoms as their FT peers, while EP adolescents might have a higher risk of asthma but have similar rates of asthma-like symptoms. RSV infections that require hospitalization are associated with an asthma diagnosis in adolescence. Clinical Trial Registration: https://www.controlled-trials.com, identifier ISRCTN 80622320.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2025.1720645

Authors: Nienke H. van Dokkum, Arend F. Bos, Sijmen A. Reijneveld, Elianne J. L. E. Vrijlandt

Institutions: University Medical Center Groningen, University of Groningen, Beatrix Kinderziekenhuis

Language: English

Topic: Asthma and respiratory diseases

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801