Work

Detection of clonal hematopoiesis of indeterminate potential via genome or exome sequencing underestimates disease associations

Year: 2026

Type: article

Abstract: Epidemiology studies underestimate the strength of the association between clonal hematopoiesis and disease due to false negatives from shallow, whole-genome sequencing versus deep targeted sequencing.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci198861

Authors: Robert Corty, Yash Pershad, J. Brett Heimlich, Caitlyn Vlasschaert, Leo Luo, Taralynn Mack, Kaushik Amancherla, Cassianne Robinson-Cohen, Michael Savona, Alexander G. Bick

Institutions: Vanderbilt University Medical Center, Queen's University, University of Washington, Vanderbilt-Ingram Cancer Center

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,200

Funders: Arthritis National Research Foundation, National Institutes of Health

Awards: BioVU Plasma Storage Equipment, G7788416786

OpenAlex ID: W7123763896

FWCI: 49.69

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Cited by: 12

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