Efficacy and Safety of VMAT2 Inhibitors in the Treatment of Huntington Disease
Year: 2026
Type: article
Study designs: Systematic Review, Meta-Analysis
Abstract: Background and Objectives: Vesicular monoamine transporter 2 inhibitors (VMAT2is) have demonstrated effectiveness in attenuating motor symptoms of Huntington disease (HD). However, evidence regarding their long-term safety and overall efficacy in this population remains limited. The aim of this study was to investigate the efficacy and safety of VMAT2is in the treatment of HD. Methods: We performed a meta-analysis of placebo-controlled, randomized controlled trials (RCTs) of VMAT2is in patients with HD. PubMed, Embase, and Cochrane databases were searched for trials up to February 8, 2025. Data were extracted from published reports, and quality assessment was performed per Cochrane recommendations. Binary end points were compared using odds ratios (ORs) while continuous end points were compared using mean difference (MD) and standardized MD (SMD), with 95% CIs for all measures. The analysis end points included changes in the Unified Huntington's Disease Rating Scale-Total Maximal Chorea (UHDRS-TMC), improvements in the Clinical Global Impression of Change (CGI-C), incidence of adverse effects, and alterations in depression scale scores. Results: = 59%). Discussion: In patients with HD, treatment with VMAT2is improved chorea (UHDRS-TMC and CGI-C), with no significant changes in adverse effects or depressive symptoms. These findings indicate that VMAT2is may be a promising and safe treatment option for the disease.
Source: Neurology Clinical Practice
Institutions: Universidade de Pernambuco, Universidade Federal de Alagoas
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7123869074